Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial
<br><strong>Objectives </strong>To determine the feasibility of conducting a randomised trial of the effectiveness of cranberry extract in reducing antibiotic use by women with symptoms of acute, uncomplicated urinary tract infection (UTI). <br><strong> Design </stro...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021
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| _version_ | 1826258769411047424 |
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| author | Gbinigie, O Allen, J Williams, N Moore, M Hay, AD Heneghan, C Boylan, A-M Butler, CC |
| author_facet | Gbinigie, O Allen, J Williams, N Moore, M Hay, AD Heneghan, C Boylan, A-M Butler, CC |
| author_sort | Gbinigie, O |
| collection | OXFORD |
| description | <br><strong>Objectives </strong>To determine the feasibility of conducting a randomised trial of the effectiveness of cranberry extract in reducing antibiotic use by women with symptoms of acute, uncomplicated urinary tract infection (UTI).
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Design </strong>Open-label feasibility randomised parallel group trial.
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Setting </strong>Four general practices in Oxfordshire.
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Participants </strong>Women aged 18 years and above presenting to general practice with symptoms of acute, uncomplicated UTI.
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Interventions</strong> Women were randomly assigned using Research Electronic Data Capture in a 1:1:1 ratio to: (1) immediate antibiotics alone (n=15); (2) immediate antibiotics and immediate cranberry capsules for up to 7 days (n=15); or (3) immediate cranberry capsules and delayed antibiotics for self-initiation in case of non-improvement or worsening of symptoms (n=16).
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Primary and secondary outcome measures </strong>The primary outcome measures were: rate of recruitment of participants; numbers lost to follow-up; proportion of electronic diaries completed by participants; and acceptability of the intervention and study procedures to participants and recruiters. Secondary outcomes included an exploration of differences in symptom burden and antibiotic use between groups.
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Results </strong>Four general practitioner practices (100%) were opened and recruited participants between 1 July and 2 December 2019, with nine study participants recruited per month on average. 68.7% (46/67) of eligible participants were randomised (target 45) with a mean age of 48.4 years (SD 19.9, range 18–81). 89.1% (41/46) of diaries contained some participant entered data and 69.6% (32/46) were fully complete. Three participants (6.5%) were lost to follow-up and two (4.4%) withdrew. Of women randomly assigned to take antibiotics alone (controls), one-third of respondents reported consuming cranberry products (33.3%, 4/12). There were no serious adverse events.
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Conclusions</strong> It appears feasible to conduct a randomised trial of the use of cranberry extract in the treatment of acute, uncomplicated UTI in general practice.
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Trial registration number </strong>ISRCTN Registry (ID: 10399299). |
| first_indexed | 2024-03-06T18:39:14Z |
| format | Journal article |
| id | oxford-uuid:0c53aabe-3608-43a5-a83a-de5d6375baf7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:39:14Z |
| publishDate | 2021 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:0c53aabe-3608-43a5-a83a-de5d6375baf72022-03-26T09:34:18ZDoes cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trialJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0c53aabe-3608-43a5-a83a-de5d6375baf7EnglishSymplectic ElementsBMJ Publishing Group2021Gbinigie, OAllen, JWilliams, NMoore, MHay, ADHeneghan, CBoylan, A-MButler, CC<br><strong>Objectives </strong>To determine the feasibility of conducting a randomised trial of the effectiveness of cranberry extract in reducing antibiotic use by women with symptoms of acute, uncomplicated urinary tract infection (UTI). <br><strong> Design </strong>Open-label feasibility randomised parallel group trial. <br><strong> Setting </strong>Four general practices in Oxfordshire. <br><strong> Participants </strong>Women aged 18 years and above presenting to general practice with symptoms of acute, uncomplicated UTI. <br><strong> Interventions</strong> Women were randomly assigned using Research Electronic Data Capture in a 1:1:1 ratio to: (1) immediate antibiotics alone (n=15); (2) immediate antibiotics and immediate cranberry capsules for up to 7 days (n=15); or (3) immediate cranberry capsules and delayed antibiotics for self-initiation in case of non-improvement or worsening of symptoms (n=16). <br><strong> Primary and secondary outcome measures </strong>The primary outcome measures were: rate of recruitment of participants; numbers lost to follow-up; proportion of electronic diaries completed by participants; and acceptability of the intervention and study procedures to participants and recruiters. Secondary outcomes included an exploration of differences in symptom burden and antibiotic use between groups. <br><strong> Results </strong>Four general practitioner practices (100%) were opened and recruited participants between 1 July and 2 December 2019, with nine study participants recruited per month on average. 68.7% (46/67) of eligible participants were randomised (target 45) with a mean age of 48.4 years (SD 19.9, range 18–81). 89.1% (41/46) of diaries contained some participant entered data and 69.6% (32/46) were fully complete. Three participants (6.5%) were lost to follow-up and two (4.4%) withdrew. Of women randomly assigned to take antibiotics alone (controls), one-third of respondents reported consuming cranberry products (33.3%, 4/12). There were no serious adverse events. <br><strong> Conclusions</strong> It appears feasible to conduct a randomised trial of the use of cranberry extract in the treatment of acute, uncomplicated UTI in general practice. <br><strong> Trial registration number </strong>ISRCTN Registry (ID: 10399299). |
| spellingShingle | Gbinigie, O Allen, J Williams, N Moore, M Hay, AD Heneghan, C Boylan, A-M Butler, CC Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial |
| title | Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial |
| title_full | Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial |
| title_fullStr | Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial |
| title_full_unstemmed | Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial |
| title_short | Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial |
| title_sort | does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections cuti a feasibility randomised trial |
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