Lack of modulation of the adrenocortical response to ACTH by an opioid peptide.
Eight normal male subjects received 1 mg dexamethasone at 23.00 h and 0.5 mg on wakening followed by a physiological intravenous dose of synthetic ACTH1-24 250 ng, with and without the administration of a stable met-enkephalin analogue (guanyl-DAMME, 100 micrograms) 10 minutes prior to the ACTH. The...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1797053098072473600 |
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| author | Howlett, T Grossman, A Froud, A Perry, L Besser, G |
| author_facet | Howlett, T Grossman, A Froud, A Perry, L Besser, G |
| author_sort | Howlett, T |
| collection | OXFORD |
| description | Eight normal male subjects received 1 mg dexamethasone at 23.00 h and 0.5 mg on wakening followed by a physiological intravenous dose of synthetic ACTH1-24 250 ng, with and without the administration of a stable met-enkephalin analogue (guanyl-DAMME, 100 micrograms) 10 minutes prior to the ACTH. The opioid analogue caused no change in the peak, incremental, or incremental area under the curve responses of plasma cortisol to the ACTH. This study does not support a role for opioid peptides in the acute modulation of the adreno-cortical response to ACTH. |
| first_indexed | 2024-03-06T18:39:17Z |
| format | Journal article |
| id | oxford-uuid:0c57eefe-80ae-470e-a517-bb0a455723ed |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:39:17Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:0c57eefe-80ae-470e-a517-bb0a455723ed2022-03-26T09:34:25ZLack of modulation of the adrenocortical response to ACTH by an opioid peptide.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0c57eefe-80ae-470e-a517-bb0a455723edEnglishSymplectic Elements at Oxford1991Howlett, TGrossman, AFroud, APerry, LBesser, GEight normal male subjects received 1 mg dexamethasone at 23.00 h and 0.5 mg on wakening followed by a physiological intravenous dose of synthetic ACTH1-24 250 ng, with and without the administration of a stable met-enkephalin analogue (guanyl-DAMME, 100 micrograms) 10 minutes prior to the ACTH. The opioid analogue caused no change in the peak, incremental, or incremental area under the curve responses of plasma cortisol to the ACTH. This study does not support a role for opioid peptides in the acute modulation of the adreno-cortical response to ACTH. |
| spellingShingle | Howlett, T Grossman, A Froud, A Perry, L Besser, G Lack of modulation of the adrenocortical response to ACTH by an opioid peptide. |
| title | Lack of modulation of the adrenocortical response to ACTH by an opioid peptide. |
| title_full | Lack of modulation of the adrenocortical response to ACTH by an opioid peptide. |
| title_fullStr | Lack of modulation of the adrenocortical response to ACTH by an opioid peptide. |
| title_full_unstemmed | Lack of modulation of the adrenocortical response to ACTH by an opioid peptide. |
| title_short | Lack of modulation of the adrenocortical response to ACTH by an opioid peptide. |
| title_sort | lack of modulation of the adrenocortical response to acth by an opioid peptide |
| work_keys_str_mv | AT howlettt lackofmodulationoftheadrenocorticalresponsetoacthbyanopioidpeptide AT grossmana lackofmodulationoftheadrenocorticalresponsetoacthbyanopioidpeptide AT frouda lackofmodulationoftheadrenocorticalresponsetoacthbyanopioidpeptide AT perryl lackofmodulationoftheadrenocorticalresponsetoacthbyanopioidpeptide AT besserg lackofmodulationoftheadrenocorticalresponsetoacthbyanopioidpeptide |