Anti-androgen treatment in women with acne: a controlled trial.
Ninety female patients with acne were allocated randomly to one of three groups and treated either with Diane, a high dose cyproterone acetate (CPA) regime with ethinyloestradiol, or Minovlar. The same dose of oestrogen was common to all three treatment groups. Patients were assessed every 2 months...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1986
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| _version_ | 1826258788251860992 |
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| author | Miller, J Wojnarowska, F Dowd, P Ashton, R O'Brien, T Griffiths, W Jacobs, H |
| author_facet | Miller, J Wojnarowska, F Dowd, P Ashton, R O'Brien, T Griffiths, W Jacobs, H |
| author_sort | Miller, J |
| collection | OXFORD |
| description | Ninety female patients with acne were allocated randomly to one of three groups and treated either with Diane, a high dose cyproterone acetate (CPA) regime with ethinyloestradiol, or Minovlar. The same dose of oestrogen was common to all three treatment groups. Patients were assessed every 2 months for 6 months, by grading for severity of the acne, lesion counts and photography, and subjectively using a visual analogue scale. In addition, bacteriological sampling and sebum excretion rate (SER) measurements were performed. The results showed a clinical improvement in all three treatment groups, but a more rapid and complete response was seen in those groups who received CPA. There was also a consistent trend suggesting a more favourable response in those in the high dose CPA group. Although there was a marked reduction in SER in the groups treated with CPA, there was no correlation between reduction in SER and clinical improvement in individuals, nor could a reduction in the surface bacterial population be shown to be a primary event in the success of anti-androgen therapy. We have shown that the addition of CPA to oestrogen adds significantly to the therapeutic effect in acne and that anti-androgen and oestrogen combinations are more effective than standard oestrogen and progestagen contraceptive pills. |
| first_indexed | 2024-03-06T18:39:32Z |
| format | Journal article |
| id | oxford-uuid:0c69922e-ea28-4016-8bab-f2b648a4fc12 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:39:32Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:0c69922e-ea28-4016-8bab-f2b648a4fc122022-03-26T09:34:49ZAnti-androgen treatment in women with acne: a controlled trial.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0c69922e-ea28-4016-8bab-f2b648a4fc12EnglishSymplectic Elements at Oxford1986Miller, JWojnarowska, FDowd, PAshton, RO'Brien, TGriffiths, WJacobs, HNinety female patients with acne were allocated randomly to one of three groups and treated either with Diane, a high dose cyproterone acetate (CPA) regime with ethinyloestradiol, or Minovlar. The same dose of oestrogen was common to all three treatment groups. Patients were assessed every 2 months for 6 months, by grading for severity of the acne, lesion counts and photography, and subjectively using a visual analogue scale. In addition, bacteriological sampling and sebum excretion rate (SER) measurements were performed. The results showed a clinical improvement in all three treatment groups, but a more rapid and complete response was seen in those groups who received CPA. There was also a consistent trend suggesting a more favourable response in those in the high dose CPA group. Although there was a marked reduction in SER in the groups treated with CPA, there was no correlation between reduction in SER and clinical improvement in individuals, nor could a reduction in the surface bacterial population be shown to be a primary event in the success of anti-androgen therapy. We have shown that the addition of CPA to oestrogen adds significantly to the therapeutic effect in acne and that anti-androgen and oestrogen combinations are more effective than standard oestrogen and progestagen contraceptive pills. |
| spellingShingle | Miller, J Wojnarowska, F Dowd, P Ashton, R O'Brien, T Griffiths, W Jacobs, H Anti-androgen treatment in women with acne: a controlled trial. |
| title | Anti-androgen treatment in women with acne: a controlled trial. |
| title_full | Anti-androgen treatment in women with acne: a controlled trial. |
| title_fullStr | Anti-androgen treatment in women with acne: a controlled trial. |
| title_full_unstemmed | Anti-androgen treatment in women with acne: a controlled trial. |
| title_short | Anti-androgen treatment in women with acne: a controlled trial. |
| title_sort | anti androgen treatment in women with acne a controlled trial |
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