Host control of the microbiome: mechanisms, evolution, and disease
Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus on how hosts affect their microbiomes. Hosts exert control over their symbionts through diverse mechanisms, includin...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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American Association for the Advancement of Science
2024
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| _version_ | 1811140206124859392 |
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| author | Wilde, J Slack, E Foster, KR |
| author_facet | Wilde, J Slack, E Foster, KR |
| author_sort | Wilde, J |
| collection | OXFORD |
| description | Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus on how hosts affect their microbiomes. Hosts exert control over their symbionts through diverse mechanisms, including immunity, barrier function, physiological homeostasis, and transit. These mechanisms enable hosts to shape the ecology and evolution of microbiomes and generate natural selection for microbial traits that benefit the host. Our microbiomes result from a perpetual tension between host control and symbiont evolution, and we can leverage the host's evolved abilities to regulate the microbiota to prevent and treat disease. The study of host control will be central to our ability to both understand and manipulate microbiotas for better health. |
| first_indexed | 2024-09-25T04:18:17Z |
| format | Journal article |
| id | oxford-uuid:0c733e3c-34a6-412a-a70c-248c6a42444f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:18:17Z |
| publishDate | 2024 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:0c733e3c-34a6-412a-a70c-248c6a42444f2024-07-25T09:36:39ZHost control of the microbiome: mechanisms, evolution, and diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0c733e3c-34a6-412a-a70c-248c6a42444fEnglishSymplectic ElementsAmerican Association for the Advancement of Science2024Wilde, JSlack, EFoster, KRMany species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus on how hosts affect their microbiomes. Hosts exert control over their symbionts through diverse mechanisms, including immunity, barrier function, physiological homeostasis, and transit. These mechanisms enable hosts to shape the ecology and evolution of microbiomes and generate natural selection for microbial traits that benefit the host. Our microbiomes result from a perpetual tension between host control and symbiont evolution, and we can leverage the host's evolved abilities to regulate the microbiota to prevent and treat disease. The study of host control will be central to our ability to both understand and manipulate microbiotas for better health. |
| spellingShingle | Wilde, J Slack, E Foster, KR Host control of the microbiome: mechanisms, evolution, and disease |
| title | Host control of the microbiome: mechanisms, evolution, and disease |
| title_full | Host control of the microbiome: mechanisms, evolution, and disease |
| title_fullStr | Host control of the microbiome: mechanisms, evolution, and disease |
| title_full_unstemmed | Host control of the microbiome: mechanisms, evolution, and disease |
| title_short | Host control of the microbiome: mechanisms, evolution, and disease |
| title_sort | host control of the microbiome mechanisms evolution and disease |
| work_keys_str_mv | AT wildej hostcontrolofthemicrobiomemechanismsevolutionanddisease AT slacke hostcontrolofthemicrobiomemechanismsevolutionanddisease AT fosterkr hostcontrolofthemicrobiomemechanismsevolutionanddisease |