Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylati...

Полное описание

Библиографические подробности
Главные авторы:	Slee, E, Lu, X
Формат:	Journal article
Язык:	English
Опубликовано:	Springer Nature 2013

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