Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylati...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Slee, E, Lu, X
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Springer Nature 2013

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