Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems
An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2017
|
| _version_ | 1826258837540175872 |
|---|---|
| author | Josa-Culleré, L Towers, C Willenbrock, F Macaulay, V Christensen, K Moloney, M |
| author_facet | Josa-Culleré, L Towers, C Willenbrock, F Macaulay, V Christensen, K Moloney, M |
| author_sort | Josa-Culleré, L |
| collection | OXFORD |
| description | An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation of reaction conditions. These systems display both weak antibacterial activity and proteasome inhibition. |
| first_indexed | 2024-03-06T18:40:18Z |
| format | Journal article |
| id | oxford-uuid:0ca53d31-83ad-44fa-97f6-f1114995a61b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:40:18Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:0ca53d31-83ad-44fa-97f6-f1114995a61b2022-03-26T09:36:09ZSynthesis and bioactivity of fused- and spiro-β-lactone-lactam systemsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0ca53d31-83ad-44fa-97f6-f1114995a61bEnglishSymplectic Elements at OxfordRoyal Society of Chemistry2017Josa-Culleré, LTowers, CWillenbrock, FMacaulay, VChristensen, KMoloney, MAn investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation of reaction conditions. These systems display both weak antibacterial activity and proteasome inhibition. |
| spellingShingle | Josa-Culleré, L Towers, C Willenbrock, F Macaulay, V Christensen, K Moloney, M Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems |
| title | Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems |
| title_full | Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems |
| title_fullStr | Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems |
| title_full_unstemmed | Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems |
| title_short | Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems |
| title_sort | synthesis and bioactivity of fused and spiro β lactone lactam systems |
| work_keys_str_mv | AT josacullerel synthesisandbioactivityoffusedandspiroblactonelactamsystems AT towersc synthesisandbioactivityoffusedandspiroblactonelactamsystems AT willenbrockf synthesisandbioactivityoffusedandspiroblactonelactamsystems AT macaulayv synthesisandbioactivityoffusedandspiroblactonelactamsystems AT christensenk synthesisandbioactivityoffusedandspiroblactonelactamsystems AT moloneym synthesisandbioactivityoffusedandspiroblactonelactamsystems |