Synthesis and bioactivity of fused- and spiro-β-lactone-lactam systems

An investigation of the formation of fused- and spiro-β-lactone annulate to γ-lactams has shown that the fused systems are formed preferentially, under standard conditions, but that spiro systems are accessible only when the formation of the fused system is blocked and require careful optimisation o...

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Detalhes bibliográficos
Main Authors: Josa-Culleré, L, Towers, C, Willenbrock, F, Macaulay, V, Christensen, K, Moloney, M
Formato: Journal article
Idioma:English
Publicado em: Royal Society of Chemistry 2017