Systematic identification of genomic markers of drug sensitivity in cancer cells

Systematic identification of genomic markers of drug sensitivity in cancer cells

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hu...

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Main Authors: Garnett, MJ, Edelman, EJ, Heidorn, SJ, Greenman, CD, Dastur, A, Lau, KW, Greninger, P, Thompson, IR, Luo, X, Soares, J, Liu, Q, Iorio, F, Surdez, D, Chen, L, Milano, RJ, Bignell, GR, Tam, AT, Davies, H, Stevenson, JA, Barthorpe, S, Lutz, SR, Lawrence, K, Haber, DA, McLaren-Douglas, A, Mitropoulos, X, Mironenko, T, Thi, H, Richardson, L, Zhou, W, Jewitt, F, Zhang, T, O'Brien, P, Boisvert, JL, Price, S, Hur, W, Yang, W, Deng, X, Butler, A, Choi, HG, Chang, JW, Baselga, J, Stamenkovic, I, Engelman, JA, Sharma, SV, Delattre, O, Saez-Rodriguez, J, Gray, NS, Settleman, J, Futreal, PA, Ramaswamy, S, Stratton, MR, McDermott, U, Benes, CH
Format: Journal article
Language:English
Published: Springer Nature 2012

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