Pharmacological inhibition of the methyltransferases SUV4-20 in cellular models of Friedreich’s ataxia
FRDA is the most common hereditary ataxia in the western world. The disorder is characterised by a pathological GAA trinucleotide repeat expansion in the FXN gene, resulting in a decrease in the expression of its encoded protein, frataxin. Symptoms commonly arise during adolescence, with patients ex...
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| Format: | Thesis |
| Language: | English |
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2021
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