A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids
<jats:p> Numerous pairs of evolutionarily divergent mammalian species have been shown to produce hybrid offspring. In some cases, F <jats:sub>1</jats:sub> hybrids are able to produce F <jats:sub>2...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
The Royal Society
2020
|
| _version_ | 1797053223652032512 |
|---|---|
| author | Allen, R Ryan, H Davis, BW King, C Frantz, L Irving-Pease, E Barnett, R Linderholm, A Loog, L Haile, J Lebrasseur, O White, M Kitchener, AC Murphy, WJ Larson, G |
| author_facet | Allen, R Ryan, H Davis, BW King, C Frantz, L Irving-Pease, E Barnett, R Linderholm, A Loog, L Haile, J Lebrasseur, O White, M Kitchener, AC Murphy, WJ Larson, G |
| author_sort | Allen, R |
| collection | OXFORD |
| description | <jats:p>
Numerous pairs of evolutionarily divergent mammalian species have been shown to produce hybrid offspring. In some cases, F
<jats:sub>1</jats:sub>
hybrids are able to produce F
<jats:sub>2</jats:sub>
s through matings with F
<jats:sub>1</jats:sub>
s. In other instances, the hybrids are only able to produce offspring themselves through backcrosses with a parent species owing to unisexual sterility (Haldane's Rule). Here, we explicitly tested whether genetic distance, computed from mitochondrial and nuclear genes, can be used as a proxy to predict the relative fertility of the hybrid offspring resulting from matings between species of terrestrial mammals. We assessed the proxy's predictive power using a well-characterized felid hybrid system, and applied it to modern and ancient hominins. Our results revealed a small overlap in mitochondrial genetic distance values that distinguish species pairs whose calculated distances fall within two categories: those whose hybrid offspring follow Haldane's Rule, and those whose hybrid F
<jats:sub>1</jats:sub>
offspring can produce F
<jats:sub>2</jats:sub>
s. The strong correlation between genetic distance and hybrid fertility demonstrated here suggests that this proxy can be employed to predict whether the hybrid offspring of two mammalian species will follow Haldane's Rule.
</jats:p> |
| first_indexed | 2024-03-06T18:40:56Z |
| format | Journal article |
| id | oxford-uuid:0cd6e421-fd76-4026-8344-4d07a0e03e73 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:40:56Z |
| publishDate | 2020 |
| publisher | The Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:0cd6e421-fd76-4026-8344-4d07a0e03e732022-03-26T09:37:17ZA mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybridsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0cd6e421-fd76-4026-8344-4d07a0e03e73EnglishSymplectic ElementsThe Royal Society2020Allen, RRyan, HDavis, BWKing, CFrantz, LIrving-Pease, EBarnett, RLinderholm, ALoog, LHaile, JLebrasseur, OWhite, MKitchener, ACMurphy, WJLarson, G<jats:p> Numerous pairs of evolutionarily divergent mammalian species have been shown to produce hybrid offspring. In some cases, F <jats:sub>1</jats:sub> hybrids are able to produce F <jats:sub>2</jats:sub> s through matings with F <jats:sub>1</jats:sub> s. In other instances, the hybrids are only able to produce offspring themselves through backcrosses with a parent species owing to unisexual sterility (Haldane's Rule). Here, we explicitly tested whether genetic distance, computed from mitochondrial and nuclear genes, can be used as a proxy to predict the relative fertility of the hybrid offspring resulting from matings between species of terrestrial mammals. We assessed the proxy's predictive power using a well-characterized felid hybrid system, and applied it to modern and ancient hominins. Our results revealed a small overlap in mitochondrial genetic distance values that distinguish species pairs whose calculated distances fall within two categories: those whose hybrid offspring follow Haldane's Rule, and those whose hybrid F <jats:sub>1</jats:sub> offspring can produce F <jats:sub>2</jats:sub> s. The strong correlation between genetic distance and hybrid fertility demonstrated here suggests that this proxy can be employed to predict whether the hybrid offspring of two mammalian species will follow Haldane's Rule. </jats:p> |
| spellingShingle | Allen, R Ryan, H Davis, BW King, C Frantz, L Irving-Pease, E Barnett, R Linderholm, A Loog, L Haile, J Lebrasseur, O White, M Kitchener, AC Murphy, WJ Larson, G A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| title | A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| title_full | A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| title_fullStr | A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| title_full_unstemmed | A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| title_short | A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| title_sort | mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids |
| work_keys_str_mv | AT allenr amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT ryanh amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT davisbw amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT kingc amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT frantzl amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT irvingpeasee amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT barnettr amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT linderholma amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT loogl amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT hailej amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT lebrasseuro amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT whitem amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT kitchenerac amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT murphywj amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT larsong amitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT allenr mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT ryanh mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT davisbw mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT kingc mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT frantzl mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT irvingpeasee mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT barnettr mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT linderholma mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT loogl mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT hailej mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT lebrasseuro mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT whitem mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT kitchenerac mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT murphywj mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids AT larsong mitochondrialgeneticdivergenceproxypredictsthereproductivecompatibilityofmammalianhybrids |