Use of lithium (alpha-methylbenzyl)allylamide for a formal asymmetric synthesis of thienamycin
The highly stereoselective conjugate addition of lithium (αR)-(α-methylbenzyl)allylamide 3 to (E)-tert-butyl penta-2,4-dienoate 4, followed by a stereoselective aldol reaction with acetaldehyde, are the key steps in the synthesis of the known β-lactam intermediate, (3S,4R)-3-E(R)-1-(tert-butyldimeth...
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| Format: | Journal article |
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1997
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