DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells
Glucocorticoid-induced TNFR-related protein (GITR) is constitutively expressed in T regulatory (Treg) cells and regulates their suppressive function. We identified two methylated CpG islands in the Gitr locus. Using a ChIP assay, we demonstrate that both DNMT1 and methyl-CpG-binding domain Protein 4...
Main Authors: | Wang, S, Li, Y, Zhu, F, Lin, F, Luo, X, Zhao, B, Zhang, P, Li, D, Gao, Y, Liang, R, Liu, L, Tsun, A, Yuan, X, Wu, K, Li, B |
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Format: | Journal article |
Language: | English |
Published: |
Wiley
2017
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