Efficient immune responses in mice lacking N-region diversity.
Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wil...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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| _version_ | 1797053361737957376 |
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| author | Gilfillan, S Bachmann, M Trembleau, S Adorini, L Kalinke, U Zinkernagel, R Benoist, C Mathis, D |
| author_facet | Gilfillan, S Bachmann, M Trembleau, S Adorini, L Kalinke, U Zinkernagel, R Benoist, C Mathis, D |
| author_sort | Gilfillan, S |
| collection | OXFORD |
| description | Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wild-type controls. We find surprisingly normal immune responses in TdT0 mice, as regards both efficiency and specificity. This provokes a reconsideration of the assumption that N-region diversity is required for an effective T and B cell repertoire. |
| first_indexed | 2024-03-06T18:42:46Z |
| format | Journal article |
| id | oxford-uuid:0d7515da-052f-4209-abd1-96b025a17749 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:42:46Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:0d7515da-052f-4209-abd1-96b025a177492022-03-26T09:40:39ZEfficient immune responses in mice lacking N-region diversity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0d7515da-052f-4209-abd1-96b025a17749EnglishSymplectic Elements at Oxford1995Gilfillan, SBachmann, MTrembleau, SAdorini, LKalinke, UZinkernagel, RBenoist, CMathis, DMice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wild-type controls. We find surprisingly normal immune responses in TdT0 mice, as regards both efficiency and specificity. This provokes a reconsideration of the assumption that N-region diversity is required for an effective T and B cell repertoire. |
| spellingShingle | Gilfillan, S Bachmann, M Trembleau, S Adorini, L Kalinke, U Zinkernagel, R Benoist, C Mathis, D Efficient immune responses in mice lacking N-region diversity. |
| title | Efficient immune responses in mice lacking N-region diversity. |
| title_full | Efficient immune responses in mice lacking N-region diversity. |
| title_fullStr | Efficient immune responses in mice lacking N-region diversity. |
| title_full_unstemmed | Efficient immune responses in mice lacking N-region diversity. |
| title_short | Efficient immune responses in mice lacking N-region diversity. |
| title_sort | efficient immune responses in mice lacking n region diversity |
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