Efficient immune responses in mice lacking N-region diversity.
Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wil...
Main Authors: | Gilfillan, S, Bachmann, M, Trembleau, S, Adorini, L, Kalinke, U, Zinkernagel, R, Benoist, C, Mathis, D |
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Format: | Journal article |
Language: | English |
Published: |
1995
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