Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial
<strong>Objective:</strong> We sought to establish whether CPAP for OSA in people with type 2 diabetes and diabetic macular oedema (DME) improved visual acuity. <strong>Methods:</strong> We randomly assigned 131 eligible patients aged 30–85 years from 23 UK centres with sign...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
European Respiratory Society
2018
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| _version_ | 1797053366502686720 |
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| author | West, SD Prudon, B Hughes, J Gupta, R Mohammed, SB Gerry, S Stradling, JR Rosa Trial Investigators |
| author_facet | West, SD Prudon, B Hughes, J Gupta, R Mohammed, SB Gerry, S Stradling, JR Rosa Trial Investigators |
| author_sort | West, SD |
| collection | OXFORD |
| description | <strong>Objective:</strong> We sought to establish whether CPAP for OSA in people with type 2 diabetes and diabetic macular oedema (DME) improved visual acuity. <strong>Methods:</strong> We randomly assigned 131 eligible patients aged 30–85 years from 23 UK centres with significant DME causing visual impairment (LogMAR letters identified, ≥ 39–≤ 78, score 0.92–0.14) plus severe OSA on screening to either: usual ophthalmology care (n=67) or usual ophthalmology care plus CPAP (n=64) for 12 months. <strong>Results:</strong> Mean age of participants was 64 years, 73% male, mean BMI 35.0 kg·m−2. Mean 4% oxygen desaturation index was 36/hour. There was no significant difference in the visual acuity at twelve months between the CPAP group and the control group, mean LogMAR (95%CI) 0.33 (0.29, 0.37) versus 0.31 (0.27, 0.35), p=0.39, and no significant correlation between change in LogMAR and average CPAP use. The median daily CPAP use (sd, range) was 3.33 (2.25, 0–7.93) hours at three months, 3.19 (2.54, 0–8.07) hours at six months and 3.21 (2.7, 0–7.98) hours at twelve months. <strong>Conclusion:</strong> CPAP therapy for OSA did not improve visual acuity in people with type 2 iabetes and diabetic macular oedema compared to usual care alone over 12 months. |
| first_indexed | 2024-03-06T18:42:50Z |
| format | Journal article |
| id | oxford-uuid:0d7ad511-4fe3-49eb-b2f1-15e2534b729d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:42:50Z |
| publishDate | 2018 |
| publisher | European Respiratory Society |
| record_format | dspace |
| spelling | oxford-uuid:0d7ad511-4fe3-49eb-b2f1-15e2534b729d2022-03-26T09:40:47ZContinuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trialJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0d7ad511-4fe3-49eb-b2f1-15e2534b729dEnglishSymplectic Elements at OxfordEuropean Respiratory Society2018West, SDPrudon, BHughes, JGupta, RMohammed, SBGerry, SStradling, JRRosa Trial Investigators<strong>Objective:</strong> We sought to establish whether CPAP for OSA in people with type 2 diabetes and diabetic macular oedema (DME) improved visual acuity. <strong>Methods:</strong> We randomly assigned 131 eligible patients aged 30–85 years from 23 UK centres with significant DME causing visual impairment (LogMAR letters identified, ≥ 39–≤ 78, score 0.92–0.14) plus severe OSA on screening to either: usual ophthalmology care (n=67) or usual ophthalmology care plus CPAP (n=64) for 12 months. <strong>Results:</strong> Mean age of participants was 64 years, 73% male, mean BMI 35.0 kg·m−2. Mean 4% oxygen desaturation index was 36/hour. There was no significant difference in the visual acuity at twelve months between the CPAP group and the control group, mean LogMAR (95%CI) 0.33 (0.29, 0.37) versus 0.31 (0.27, 0.35), p=0.39, and no significant correlation between change in LogMAR and average CPAP use. The median daily CPAP use (sd, range) was 3.33 (2.25, 0–7.93) hours at three months, 3.19 (2.54, 0–8.07) hours at six months and 3.21 (2.7, 0–7.98) hours at twelve months. <strong>Conclusion:</strong> CPAP therapy for OSA did not improve visual acuity in people with type 2 iabetes and diabetic macular oedema compared to usual care alone over 12 months. |
| spellingShingle | West, SD Prudon, B Hughes, J Gupta, R Mohammed, SB Gerry, S Stradling, JR Rosa Trial Investigators Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial |
| title | Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial |
| title_full | Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial |
| title_fullStr | Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial |
| title_full_unstemmed | Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial |
| title_short | Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial |
| title_sort | continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea a multicentre randomised controlled trial |
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