Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations

Dominant mutations in the mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2) and CHCHD10 (C10) were recently identified as causing Parkinson's disease and amyotrophic lateral sclerosis/frontotemporal dementia/myopathy, respectively. The mechanism by which they disrupt mitoch...

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Bibliographic Details
Main Authors:	Liu, Y-T, Huang, X, Nguyen, D, Shammas, MK, Wu, BP, Dombi, E, Springer, DA, Poulton, J, Sekine, S, Narendra, DP
Format:	Journal article
Language:	English
Published:	Oxford University Press 2020

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