Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study.
We examined the relation between plasma total homocysteine (tHcy), folate, vitamin B12, and episodic memory in elderly community-dwelling subjects. A population-based study was conducted in 1992 and 1993, and subjects were re-investigated after 6 years. Plasma analytes were determined on both occasi...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797053415015055360 |
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| author | Nurk, E Refsum, H Tell, G Engedal, K Vollset, SE Ueland, P Nygaard, H Smith, A |
| author_facet | Nurk, E Refsum, H Tell, G Engedal, K Vollset, SE Ueland, P Nygaard, H Smith, A |
| author_sort | Nurk, E |
| collection | OXFORD |
| description | We examined the relation between plasma total homocysteine (tHcy), folate, vitamin B12, and episodic memory in elderly community-dwelling subjects. A population-based study was conducted in 1992 and 1993, and subjects were re-investigated after 6 years. Plasma analytes were determined on both occasions. At follow-up, memory performance, using the Kendrick Object Learning Test, was investigated in 2,189 subjects (age, 65-67 years at baseline). Subjects with memory deficit (test score, < 25) had higher tHcy and lower folate at follow-up compared with those without memory deficit: 12.6 (95% confidence interval [CI], 12.1, 13.1) versus 11.5 (95% CI, 11.3, 11.6) micromol/L (p < 0.001) for tHcy, and 6.7 (95% CI, 6.2, 7.1) versus 7.6 (95% CI, 7.5, 7.8) nmol/L (p < 0.001) for folate. The risk of memory deficit increased according to quintiles of tHcy both at baseline and at follow-up. A decline in tHcy, or an increase in folate, over a 6-year period was associated with a higher memory test score; and vice versa. These findings indicate that increased plasma tHcy is an independent risk factor for memory deficit both cross-sectionally and prospectively, and that a "favorable" change in folate or tHcy concentrations over time is associated with better memory performance. |
| first_indexed | 2024-03-06T18:43:25Z |
| format | Journal article |
| id | oxford-uuid:0dabd1b6-30e1-4b5c-af9d-2347a94b7f77 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:43:25Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:0dabd1b6-30e1-4b5c-af9d-2347a94b7f772022-03-26T09:41:51ZPlasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0dabd1b6-30e1-4b5c-af9d-2347a94b7f77EnglishSymplectic Elements at Oxford2005Nurk, ERefsum, HTell, GEngedal, KVollset, SEUeland, PNygaard, HSmith, AWe examined the relation between plasma total homocysteine (tHcy), folate, vitamin B12, and episodic memory in elderly community-dwelling subjects. A population-based study was conducted in 1992 and 1993, and subjects were re-investigated after 6 years. Plasma analytes were determined on both occasions. At follow-up, memory performance, using the Kendrick Object Learning Test, was investigated in 2,189 subjects (age, 65-67 years at baseline). Subjects with memory deficit (test score, < 25) had higher tHcy and lower folate at follow-up compared with those without memory deficit: 12.6 (95% confidence interval [CI], 12.1, 13.1) versus 11.5 (95% CI, 11.3, 11.6) micromol/L (p < 0.001) for tHcy, and 6.7 (95% CI, 6.2, 7.1) versus 7.6 (95% CI, 7.5, 7.8) nmol/L (p < 0.001) for folate. The risk of memory deficit increased according to quintiles of tHcy both at baseline and at follow-up. A decline in tHcy, or an increase in folate, over a 6-year period was associated with a higher memory test score; and vice versa. These findings indicate that increased plasma tHcy is an independent risk factor for memory deficit both cross-sectionally and prospectively, and that a "favorable" change in folate or tHcy concentrations over time is associated with better memory performance. |
| spellingShingle | Nurk, E Refsum, H Tell, G Engedal, K Vollset, SE Ueland, P Nygaard, H Smith, A Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. |
| title | Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. |
| title_full | Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. |
| title_fullStr | Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. |
| title_full_unstemmed | Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. |
| title_short | Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. |
| title_sort | plasma total homocysteine and memory in the elderly the hordaland homocysteine study |
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