Chemically amplified 19F-1H nuclear Overhauser effects.
Chemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance (19)F nuclear magnetisation in 3-fluorotyrosine by m...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826259068627451904 |
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| author | Kuprov, I Hore, P |
| author_facet | Kuprov, I Hore, P |
| author_sort | Kuprov, I |
| collection | OXFORD |
| description | Chemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance (19)F nuclear magnetisation in 3-fluorotyrosine by more than an order of magnitude with a corresponding increase in the amplitudes of (19)F-(1)H cross-relaxation and cross-correlation effects. The reactions employed are cyclic and leave the sample chemically unchanged. The potential for enhancing the sensitivity of heteronuclear NOEs in (19)F-labelled proteins is discussed. |
| first_indexed | 2024-03-06T18:44:02Z |
| format | Journal article |
| id | oxford-uuid:0de3231a-c8f3-4232-acf5-25824e9118be |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:44:02Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:0de3231a-c8f3-4232-acf5-25824e9118be2022-03-26T09:42:50ZChemically amplified 19F-1H nuclear Overhauser effects.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0de3231a-c8f3-4232-acf5-25824e9118beEnglishSymplectic Elements at Oxford2004Kuprov, IHore, PChemically induced dynamic nuclear polarisation (CIDNP) is explored as a source of nuclear hyperpolarisation in heteronuclear Overhauser effect experiments. A photochemical reaction proceeding through a radical pair intermediate is used to enhance (19)F nuclear magnetisation in 3-fluorotyrosine by more than an order of magnitude with a corresponding increase in the amplitudes of (19)F-(1)H cross-relaxation and cross-correlation effects. The reactions employed are cyclic and leave the sample chemically unchanged. The potential for enhancing the sensitivity of heteronuclear NOEs in (19)F-labelled proteins is discussed. |
| spellingShingle | Kuprov, I Hore, P Chemically amplified 19F-1H nuclear Overhauser effects. |
| title | Chemically amplified 19F-1H nuclear Overhauser effects. |
| title_full | Chemically amplified 19F-1H nuclear Overhauser effects. |
| title_fullStr | Chemically amplified 19F-1H nuclear Overhauser effects. |
| title_full_unstemmed | Chemically amplified 19F-1H nuclear Overhauser effects. |
| title_short | Chemically amplified 19F-1H nuclear Overhauser effects. |
| title_sort | chemically amplified 19f 1h nuclear overhauser effects |
| work_keys_str_mv | AT kuprovi chemicallyamplified19f1hnuclearoverhausereffects AT horep chemicallyamplified19f1hnuclearoverhausereffects |