Dynamics and functions of lipid droplets
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic ret...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2018
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| _version_ | 1826259081152692224 |
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| author | Olzmann, J Carvalho, P |
| author_facet | Olzmann, J Carvalho, P |
| author_sort | Olzmann, J |
| collection | OXFORD |
| description | Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic reticulum, lipid droplets can associate with most other cellular organelles through membrane contact sites. It is becoming apparent that these contacts between lipid droplets and other organelles are highly dynamic and coupled to the cycles of lipid droplet expansion and shrinkage. Importantly, lipid droplet biogenesis and degradation, as well as their interactions with other organelles, are tightly coupled to cellular metabolism and are critical to buffer the levels of toxic lipid species. Thus, lipid droplets facilitate the coordination and communication between different organelles and act as vital hubs of cellular metabolism. |
| first_indexed | 2024-03-06T18:44:13Z |
| format | Journal article |
| id | oxford-uuid:0df24068-df7a-4444-87d8-e0799586339c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:44:13Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:0df24068-df7a-4444-87d8-e0799586339c2022-03-26T09:43:11ZDynamics and functions of lipid dropletsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0df24068-df7a-4444-87d8-e0799586339cEnglishSymplectic Elements at OxfordSpringer Nature2018Olzmann, JCarvalho, PLipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic reticulum, lipid droplets can associate with most other cellular organelles through membrane contact sites. It is becoming apparent that these contacts between lipid droplets and other organelles are highly dynamic and coupled to the cycles of lipid droplet expansion and shrinkage. Importantly, lipid droplet biogenesis and degradation, as well as their interactions with other organelles, are tightly coupled to cellular metabolism and are critical to buffer the levels of toxic lipid species. Thus, lipid droplets facilitate the coordination and communication between different organelles and act as vital hubs of cellular metabolism. |
| spellingShingle | Olzmann, J Carvalho, P Dynamics and functions of lipid droplets |
| title | Dynamics and functions of lipid droplets |
| title_full | Dynamics and functions of lipid droplets |
| title_fullStr | Dynamics and functions of lipid droplets |
| title_full_unstemmed | Dynamics and functions of lipid droplets |
| title_short | Dynamics and functions of lipid droplets |
| title_sort | dynamics and functions of lipid droplets |
| work_keys_str_mv | AT olzmannj dynamicsandfunctionsoflipiddroplets AT carvalhop dynamicsandfunctionsoflipiddroplets |