Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55, allowing wide-spread dephosphorylation of substra...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Holder, J, Mohammed, S, Barr, FA
التنسيق:	Journal article
اللغة:	English
منشور في:	eLife Sciences Publications 2020

مواد مشابهة

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