Evaluation of loading strategies to improve tumor uptake of gemcitabine in a murine orthotopic bladder cancer model using ultrasound and microbubbles

In this study we compared three different microbubble-based approaches to the delivery of a widely used chemotherapy drug, gemcitabine: (i) co-administration of gemcitabine and microbubbles (Gem+MB); (ii) conjugates of microbubbles and gemcitabine-loaded liposomes (GemlipoMB); and (iii) microbubbles...

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Main Authors: Ruan, J-L, Browning, RJ, Yildiz, YO, Bau, L, Kamila, S, Gray, MD, Folkes, L, Hampson, A, McHale, AP, Callan, JF, Vojnovic, B, Kiltie, AE, Stride, E
Format: Journal article
Language:English
Published: Elsevier 2021