Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements. Activation of viral mimicry has the potential to kill cancer cells or augment anti-tumor immune responses. Here, we systematically identify mechanisms of viral...

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Bibliographic Details
Main Authors:	Hosseini, A, Lindholm, HT, Chen, R, Mehdipour, P, Marhon, SA, Ishak, CA, Moore, PC, Classon, M, Di Gioacchino, A, Greenbaum, B, De Carvalho, DD
Format:	Journal article
Language:	English
Published:	Cell Press 2024

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