Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms.
Polymorphic differences distinguishing MHC class I subtypes often permit the presentation of shared epitopes in conformationally identical formats but can affect T-cell repertoire selection, differentially impacting autoimmune susceptibilities and viral clearance in vivo. The molecular mechanisms un...
Main Authors: | Stewart-Jones, G, Simpson, P, Van Der Merwe, P, Easterbrook, P, Mcmichael, A, Rowland-Jones, S, Jones, E, Gillespie, G |
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Format: | Journal article |
Language: | English |
Published: |
2012
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