Illustrating the interplay between the extracellular matrix and microRNAs
The discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profoundly...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Blackwell Publishing Ltd
2014
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| _version_ | 1797053573924651008 |
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| author | Piccinini, A Midwood, K |
| author_facet | Piccinini, A Midwood, K |
| author_sort | Piccinini, A |
| collection | OXFORD |
| description | The discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profoundly affected by the ECM, whose synthesis and turnover must be finely balanced in order to maintain normal function and prevent disease. In the last decade, microRNAs (miRNAs) have emerged as key regulators of ECM gene expression. As new technologies for the identification and validation of miRNA targets continue to be developed, a growing body of data supporting the role of miRNAs in regulating the ECM biology has arisen from a variety of cell and animal models along with clinical studies. However, more recent findings suggest an intriguing interplay between the ECM and miRNAs: not only can miRNAs control the composition of the ECM, but also the ECM can affect the expression of specific miRNAs. Here we discuss how miRNAs contribute to the synthesis, maintenance and remodelling of the ECM during development and disease. Furthermore, we bring to light evidence that points to a role for the ECM in regulating miRNA expression and function. © 2014 The Authors. International Journal of Experimental Pathology © 2014 International Journal of Experimental Pathology. |
| first_indexed | 2024-03-06T18:45:33Z |
| format | Journal article |
| id | oxford-uuid:0e624414-0b17-4f6f-89c6-291745d7d083 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:45:33Z |
| publishDate | 2014 |
| publisher | Blackwell Publishing Ltd |
| record_format | dspace |
| spelling | oxford-uuid:0e624414-0b17-4f6f-89c6-291745d7d0832022-03-26T09:45:34ZIllustrating the interplay between the extracellular matrix and microRNAsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0e624414-0b17-4f6f-89c6-291745d7d083EnglishSymplectic Elements at OxfordBlackwell Publishing Ltd2014Piccinini, AMidwood, KThe discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profoundly affected by the ECM, whose synthesis and turnover must be finely balanced in order to maintain normal function and prevent disease. In the last decade, microRNAs (miRNAs) have emerged as key regulators of ECM gene expression. As new technologies for the identification and validation of miRNA targets continue to be developed, a growing body of data supporting the role of miRNAs in regulating the ECM biology has arisen from a variety of cell and animal models along with clinical studies. However, more recent findings suggest an intriguing interplay between the ECM and miRNAs: not only can miRNAs control the composition of the ECM, but also the ECM can affect the expression of specific miRNAs. Here we discuss how miRNAs contribute to the synthesis, maintenance and remodelling of the ECM during development and disease. Furthermore, we bring to light evidence that points to a role for the ECM in regulating miRNA expression and function. © 2014 The Authors. International Journal of Experimental Pathology © 2014 International Journal of Experimental Pathology. |
| spellingShingle | Piccinini, A Midwood, K Illustrating the interplay between the extracellular matrix and microRNAs |
| title | Illustrating the interplay between the extracellular matrix and microRNAs |
| title_full | Illustrating the interplay between the extracellular matrix and microRNAs |
| title_fullStr | Illustrating the interplay between the extracellular matrix and microRNAs |
| title_full_unstemmed | Illustrating the interplay between the extracellular matrix and microRNAs |
| title_short | Illustrating the interplay between the extracellular matrix and microRNAs |
| title_sort | illustrating the interplay between the extracellular matrix and micrornas |
| work_keys_str_mv | AT piccininia illustratingtheinterplaybetweentheextracellularmatrixandmicrornas AT midwoodk illustratingtheinterplaybetweentheextracellularmatrixandmicrornas |