β-Cell dysfunction in diabetes: a crisis of identity?

Type 2 diabetes is characterized by insulin resistance and a progressive loss of β-cell function induced by a combination of both β-cell loss and impaired insulin secretion from remaining β-cells. Here, we review the fate of the β-cell under chronic hyperglycaemic conditions with regard to β-cell ma...

Полное описание

Библиографические подробности
Главные авторы: Brereton, M, Rohm, M, Ashcroft, F
Формат: Journal article
Язык:English
Опубликовано: John Wiley & Sons Ltd 2016