Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma
<p>Purpose: To assess the efficacy of different schedules for combining external beam radiotherapy (EBRT) with molecular radiotherapy (MRT) using 131I-mIBG in the management of neuroblastoma.</p><p> Materials and Methods: Balb/c nu/nu mice bearing SK-N-SH neuroblastoma xe...
| Egile Nagusiak: | , , , , , , , , , , , , , |
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| Formatua: | Journal article |
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Elsevier
2017
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| _version_ | 1826259183358443520 |
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| author | Corroyer-Dulmont, A Falzone, N Kersemans, V Thompson, J Allen, D Able, S Kartsonaki, C Malcolm, J Kinchesh, P Hill, M Vojnovic, B Smart, S Gaze, M Vallis, K |
| author_facet | Corroyer-Dulmont, A Falzone, N Kersemans, V Thompson, J Allen, D Able, S Kartsonaki, C Malcolm, J Kinchesh, P Hill, M Vojnovic, B Smart, S Gaze, M Vallis, K |
| author_sort | Corroyer-Dulmont, A |
| collection | OXFORD |
| description | <p>Purpose: To assess the efficacy of different schedules for combining external beam radiotherapy (EBRT) with molecular radiotherapy (MRT) using 131I-mIBG in the management of neuroblastoma.</p><p> Materials and Methods: Balb/c nu/nu mice bearing SK-N-SH neuroblastoma xenografts were assigned to five treatment groups: 131I-mIBG 24h after EBRT, EBRT 6 days after 131I-mIBG, EBRT alone, 131I-mIBG alone and control (untreated). A total of 56 mice were assigned to 3 studies. Study 1: Vessel permeability was evaluated using dynamic contrast-enhanced (DCE)-MRI (n=3). Study 2: Tumour volume and overall survival were assessed by longitudinal MR imaging (n=25). Study 3: Tumour uptake of 131I-mIBG in excised lesions was evaluated by -counting and autoradiography (n=28). Tumour dosimetry was performed using Monte Carlo simulations of absorbed fractions with the radiation transport code PENELOPE.</p><p> Results: Given alone, both 131I-mIBG and EBRT resulted in a seven-day delay in tumour regrowth. Following EBRT, vessel permeability was evaluated by DCE-MRI and showed an increase at 24h post irradiation that correlated with an increase in 131I-mIBG tumour uptake, absorbed dose and overall survival in the case of combined treatment. Similarly, EBRT administered seven days after MRT to coincide with tumour regrowth, significantly decreased the tumour volume and increased overall survival.</p><p> Conclusions: This study demonstrates that combining EBRT and MRT has an enhanced therapeutic effect and emphasizes the importance of treatment scheduling according to pathophysiological criteria such as tumour vessel permeability and tumour growth kinetics.</p> |
| first_indexed | 2024-03-06T18:45:50Z |
| format | Journal article |
| id | oxford-uuid:0e7b83d5-c413-46be-93f2-9065680126d3 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:45:50Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:0e7b83d5-c413-46be-93f2-9065680126d32022-03-26T09:46:10ZImproved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0e7b83d5-c413-46be-93f2-9065680126d3Symplectic Elements at OxfordElsevier2017Corroyer-Dulmont, AFalzone, NKersemans, VThompson, JAllen, DAble, SKartsonaki, CMalcolm, JKinchesh, PHill, MVojnovic, BSmart, SGaze, MVallis, K<p>Purpose: To assess the efficacy of different schedules for combining external beam radiotherapy (EBRT) with molecular radiotherapy (MRT) using 131I-mIBG in the management of neuroblastoma.</p><p> Materials and Methods: Balb/c nu/nu mice bearing SK-N-SH neuroblastoma xenografts were assigned to five treatment groups: 131I-mIBG 24h after EBRT, EBRT 6 days after 131I-mIBG, EBRT alone, 131I-mIBG alone and control (untreated). A total of 56 mice were assigned to 3 studies. Study 1: Vessel permeability was evaluated using dynamic contrast-enhanced (DCE)-MRI (n=3). Study 2: Tumour volume and overall survival were assessed by longitudinal MR imaging (n=25). Study 3: Tumour uptake of 131I-mIBG in excised lesions was evaluated by -counting and autoradiography (n=28). Tumour dosimetry was performed using Monte Carlo simulations of absorbed fractions with the radiation transport code PENELOPE.</p><p> Results: Given alone, both 131I-mIBG and EBRT resulted in a seven-day delay in tumour regrowth. Following EBRT, vessel permeability was evaluated by DCE-MRI and showed an increase at 24h post irradiation that correlated with an increase in 131I-mIBG tumour uptake, absorbed dose and overall survival in the case of combined treatment. Similarly, EBRT administered seven days after MRT to coincide with tumour regrowth, significantly decreased the tumour volume and increased overall survival.</p><p> Conclusions: This study demonstrates that combining EBRT and MRT has an enhanced therapeutic effect and emphasizes the importance of treatment scheduling according to pathophysiological criteria such as tumour vessel permeability and tumour growth kinetics.</p> |
| spellingShingle | Corroyer-Dulmont, A Falzone, N Kersemans, V Thompson, J Allen, D Able, S Kartsonaki, C Malcolm, J Kinchesh, P Hill, M Vojnovic, B Smart, S Gaze, M Vallis, K Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma |
| title | Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma |
| title_full | Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma |
| title_fullStr | Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma |
| title_full_unstemmed | Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma |
| title_short | Improved outcome of 131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma |
| title_sort | improved outcome of 131i mibg treatment through combination with external beam radiotherapy in the sk n sh mouse model of neuroblastoma |
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