High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon.
Hepatitis C (HCV) molecular epidemiology is documented poorly in central African countries. In response to this, a population-based study of 319 consenting adults resident in a remote village of Gabon was undertaken (mean age: 38 years; age range: 13-85+; sex ratio: 0.74). Screening for anti-HCV ant...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1826259195037483008 |
|---|---|
| author | Ndong-Atome, G Makuwa, M Ouwe-Missi-Oukem-Boyer, O Pybus, O Branger, M Le Hello, S Boye-Cheik, S Brun-Vezinet, F Kazanji, M Roques, P Bisser, S |
| author_facet | Ndong-Atome, G Makuwa, M Ouwe-Missi-Oukem-Boyer, O Pybus, O Branger, M Le Hello, S Boye-Cheik, S Brun-Vezinet, F Kazanji, M Roques, P Bisser, S |
| author_sort | Ndong-Atome, G |
| collection | OXFORD |
| description | Hepatitis C (HCV) molecular epidemiology is documented poorly in central African countries. In response to this, a population-based study of 319 consenting adults resident in a remote village of Gabon was undertaken (mean age: 38 years; age range: 13-85+; sex ratio: 0.74). Screening for anti-HCV antibodies was performed using ELISA and recombinant immunoblot assay. Seropositive samples were assessed further with viral load and genotyping techniques. Sixty-six (20.7%) individuals were HCV seropositive. Viral loads ranged from 600 to 24.9 million IU/ml (median: 372,500). Seroprevalence and viral loads increased significantly with age (P < 10(-5) and P < 0.003, respectively). HCV sequences of the 5'UTR genome region were obtained from 60 (90.9%) samples and NS5B region sequences were obtained from 22 (36.6%) samples. All strains belonged to subtypes of genotype 4: 4e (72.7%), 4c (13.6%), 4p (4.5%), 4r (4.5%) and one unclassified genotype 4 strain. Evolutionary analysis of the subtype 4e sequences indicates a period of raised transmission during the early twentieth century. |
| first_indexed | 2024-03-06T18:46:01Z |
| format | Journal article |
| id | oxford-uuid:0e890fa1-0cdf-478f-af5c-a21abe79f135 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:46:01Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:0e890fa1-0cdf-478f-af5c-a21abe79f1352022-03-26T09:46:27ZHigh prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0e890fa1-0cdf-478f-af5c-a21abe79f135EnglishSymplectic Elements at Oxford2008Ndong-Atome, GMakuwa, MOuwe-Missi-Oukem-Boyer, OPybus, OBranger, MLe Hello, SBoye-Cheik, SBrun-Vezinet, FKazanji, MRoques, PBisser, SHepatitis C (HCV) molecular epidemiology is documented poorly in central African countries. In response to this, a population-based study of 319 consenting adults resident in a remote village of Gabon was undertaken (mean age: 38 years; age range: 13-85+; sex ratio: 0.74). Screening for anti-HCV antibodies was performed using ELISA and recombinant immunoblot assay. Seropositive samples were assessed further with viral load and genotyping techniques. Sixty-six (20.7%) individuals were HCV seropositive. Viral loads ranged from 600 to 24.9 million IU/ml (median: 372,500). Seroprevalence and viral loads increased significantly with age (P < 10(-5) and P < 0.003, respectively). HCV sequences of the 5'UTR genome region were obtained from 60 (90.9%) samples and NS5B region sequences were obtained from 22 (36.6%) samples. All strains belonged to subtypes of genotype 4: 4e (72.7%), 4c (13.6%), 4p (4.5%), 4r (4.5%) and one unclassified genotype 4 strain. Evolutionary analysis of the subtype 4e sequences indicates a period of raised transmission during the early twentieth century. |
| spellingShingle | Ndong-Atome, G Makuwa, M Ouwe-Missi-Oukem-Boyer, O Pybus, O Branger, M Le Hello, S Boye-Cheik, S Brun-Vezinet, F Kazanji, M Roques, P Bisser, S High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon. |
| title | High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon. |
| title_full | High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon. |
| title_fullStr | High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon. |
| title_full_unstemmed | High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon. |
| title_short | High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural Gabon. |
| title_sort | high prevalence of hepatitis c virus infection and predominance of genotype 4 in rural gabon |
| work_keys_str_mv | AT ndongatomeg highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT makuwam highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT ouwemissioukemboyero highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT pybuso highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT brangerm highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT lehellos highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT boyecheiks highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT brunvezinetf highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT kazanjim highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT roquesp highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon AT bissers highprevalenceofhepatitiscvirusinfectionandpredominanceofgenotype4inruralgabon |