RIPK2 NODs to XIAP and IBD
The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiate...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2020
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| _version_ | 1826259236809605120 |
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| author | Topal, Y Gyrd-Hansen, M |
| author_facet | Topal, Y Gyrd-Hansen, M |
| author_sort | Topal, Y |
| collection | OXFORD |
| description | The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Recent advances suggest that the interaction between RIPK2 and XIAP is a druggable protein-protein interaction to modulate NOD1/2-dependent immune responses. Here, we discuss the mechanistic function of RIPK2 in immune signalling, its clinical relevance, and the on-going efforts to target RIPK2 in inflammatory bowel disease and beyond.
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| first_indexed | 2024-03-06T18:46:42Z |
| format | Journal article |
| id | oxford-uuid:0ec1c806-6097-444a-940a-28b835f6fc28 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:46:42Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:0ec1c806-6097-444a-940a-28b835f6fc282022-03-26T09:47:38ZRIPK2 NODs to XIAP and IBDJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0ec1c806-6097-444a-940a-28b835f6fc28EnglishSymplectic ElementsElsevier2020Topal, YGyrd-Hansen, MThe receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Recent advances suggest that the interaction between RIPK2 and XIAP is a druggable protein-protein interaction to modulate NOD1/2-dependent immune responses. Here, we discuss the mechanistic function of RIPK2 in immune signalling, its clinical relevance, and the on-going efforts to target RIPK2 in inflammatory bowel disease and beyond. |
| spellingShingle | Topal, Y Gyrd-Hansen, M RIPK2 NODs to XIAP and IBD |
| title | RIPK2 NODs to XIAP and IBD |
| title_full | RIPK2 NODs to XIAP and IBD |
| title_fullStr | RIPK2 NODs to XIAP and IBD |
| title_full_unstemmed | RIPK2 NODs to XIAP and IBD |
| title_short | RIPK2 NODs to XIAP and IBD |
| title_sort | ripk2 nods to xiap and ibd |
| work_keys_str_mv | AT topaly ripk2nodstoxiapandibd AT gyrdhansenm ripk2nodstoxiapandibd |