Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.

Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.

Glucocorticoid-induced TNFR (Gitr) and Ox40, two members of the TNFR superfamily, play important roles in regulating activities of effector and regulatory T cells (Treg). Their gene expression is induced by T cell activation and further upregulated in Foxp3+ Treg. Although the role of Foxp3 as a tra...

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Bibliographic Details
Main Authors:	Tone, Y, Kidani, Y, Ogawa, C, Yamamoto, K, Tsuda, M, Peter, C, Waldmann, H, Tone, M
Format:	Journal article
Language:	English
Published:	American Association of Immunologists 2014

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