Cyclin-dependent kinase 12 (CDK12), human kinase domain; a Target Enabling Package
A description of the materials and methods is included within the TEP datasheet. Cyclin-dependent kinase 12 (CDK12) phosphorylates RNA Pol II C-terminal domain (CTD) to promote transcriptional elongation of large DNA damage response genes. CDK12 is frequently mutated or amplified in cancer and its l...
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University of Oxford
2018
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