Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Colistin has emerged as an important last line of defence for the treatment of infections caused by antibiotic resistant Gram-negative pathogens, but colistin resistance remains poorly understood. Here we investigate the responses of |1,000 populations of an MDR strain of P. aeruginosa to a high dos...

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Autors principals: Kapel, N, diaz, J, Maclean, R
Format: Journal article
Idioma:English
Publicat: Cell Press 2022

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