Localized pmrB hypermutation drives the evolution of colistin heteroresistance
Colistin has emerged as an important last line of defence for the treatment of infections caused by antibiotic resistant Gram-negative pathogens, but colistin resistance remains poorly understood. Here we investigate the responses of |1,000 populations of an MDR strain of P. aeruginosa to a high dos...
Autors principals: | Kapel, N, diaz, J, Maclean, R |
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Format: | Journal article |
Idioma: | English |
Publicat: |
Cell Press
2022
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