Localized pmrB hypermutation drives the evolution of colistin heteroresistance
Colistin has emerged as an important last line of defence for the treatment of infections caused by antibiotic resistant Gram-negative pathogens, but colistin resistance remains poorly understood. Here we investigate the responses of |1,000 populations of an MDR strain of P. aeruginosa to a high dos...
Κύριοι συγγραφείς: | Kapel, N, diaz, J, Maclean, R |
---|---|
Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
Cell Press
2022
|
Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
-
Localized hypermutation drives the evolution of colistin heteroresistance
ανά: MacLean, C, κ.ά.
Έκδοση: (2022) -
Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa
ανά: Romano, Keith P., κ.ά.
Έκδοση: (2020) -
Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli
ανά: Jung-Chung Lin, κ.ά.
Έκδοση: (2024-09-01) -
PmrB Y358N, E123D amino acid substitutions are not associated with colistin resistance but with phylogeny in Escherichia coli
ανά: Alyssa Butters, κ.ά.
Έκδοση: (2024-10-01) -
Upregulation of pmrA, pmrB, pmrC, phoQ, phoP, and arnT genes contributing to resistance to colistin in superbug Klebsiella pneumoniae isolates from human clinical samples in Tehran, Iran
ανά: Maryam Mirshekar, κ.ά.
Έκδοση: (2024-06-01)