Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Colistin has emerged as an important last line of defence for the treatment of infections caused by antibiotic resistant Gram-negative pathogens, but colistin resistance remains poorly understood. Here we investigate the responses of |1,000 populations of an MDR strain of P. aeruginosa to a high dos...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Kapel, N, diaz, J, Maclean, R
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Cell Press 2022

समान संसाधन

Localized hypermutation drives the evolution of colistin heteroresistance
द्वारा: MacLean, C, और अन्य
प्रकाशित: (2022)

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa
द्वारा: Romano, Keith P., और अन्य
प्रकाशित: (2020)

Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli
द्वारा: Jung-Chung Lin, और अन्य
प्रकाशित: (2024-09-01)

PmrB Y358N, E123D amino acid substitutions are not associated with colistin resistance but with phylogeny in Escherichia coli
द्वारा: Alyssa Butters, और अन्य
प्रकाशित: (2024-10-01)

Upregulation of pmrA, pmrB, pmrC, phoQ, phoP, and arnT genes contributing to resistance to colistin in superbug Klebsiella pneumoniae isolates from human clinical samples in Tehran, Iran
द्वारा: Maryam Mirshekar, और अन्य
प्रकाशित: (2024-06-01)

Two types of colistin heteroresistance in Acinetobacter baumannii isolates
द्वारा: Yoon-Kyoung Hong, और अन्य
प्रकाशित: (2020-01-01)

Systematic review and meta-analysis of colistin heteroresistance in Klebsiella pneumoniae isolates
द्वारा: Saeed Khoshnood, और अन्य
प्रकाशित: (2025-02-01)

Development of colistin resistance via heteroresistance modeling in : A diagnostic study
द्वारा: Jungyu Seo, और अन्य
प्रकाशित: (2024-03-01)

Clinical characteristics, molecular epidemiology and mechanisms of colistin heteroresistance in Enterobacter cloacae complex
द्वारा: Chunli Wei, और अन्य
प्रकाशित: (2025-03-01)

Study of the mechanisms of colistin heteroresistance in a strain of Enterobacter cloacae by random mutagenesis
द्वारा: Romane Milleville, और अन्य
प्रकाशित: (2024-12-01)

Assessment of Colistin Heteroresistance among Multidrug-Resistant <i>Klebsiella pneumoniae</i> Isolated from Intensive Care Patients in Europe
द्वारा: Anouk J. M. M. Braspenning, और अन्य
प्रकाशित: (2024-03-01)

Influence of PhoPQ and PmrAB two component system alternations on colistin resistance from non-mcr colistin resistant clinical E. Coli strains
द्वारा: Ching-Hsun Wang, और अन्य
प्रकाशित: (2024-04-01)

Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii
द्वारा: Maria Romano, और अन्य
प्रकाशित: (2024-11-01)

A Mobile Element in mutS Drives Hypermutation in a Marine Vibrio
द्वारा: Chu, Nathaniel David, और अन्य
प्रकाशित: (2017)

PASSPORT PMR /
द्वारा: Lim, Anita, author 654514, और अन्य
प्रकाशित: (2012)

Somatic hypermutation signature in B-cell low-grade lymphomas
द्वारा: Lorraine Tracey, और अन्य
प्रकाशित: (2008-08-01)

Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection
द्वारा: Wheatley, R, और अन्य
प्रकाशित: (2021)

Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance
द्वारा: Linna Xu, और अन्य
प्रकाशित: (2025-01-01)

Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms
द्वारा: LI Yanbing, और अन्य
प्रकाशित: (2024-11-01)

Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
द्वारा: Yanyu Su, और अन्य
प्रकाशित: (2025-02-01)

Vancomycin heteroresistance in Staphylococcus haemolyticus: elusive phenotype
द्वारा: Yamuna Devi Bathavatchalam, और अन्य
प्रकाशित: (2021-08-01)

Laporan prestasi PMR /
द्वारा: Malaysia. Kementerian Pendidikan. Lembaga Peperiksaan
प्रकाशित: ([19-)

Seminar PMR 2012
द्वारा: Berita, Harian
प्रकाशित: (2012)

Sekitar PMR 2012
द्वारा: Berita, Harian
प्रकाशित: (2012)

Sekitar PMR 2012
द्वारा: Berita, Harian
प्रकाशित: (2012)

Cross-talk between QseBC and PmrAB two-component systems is crucial for regulation of motility and colistin resistance in Enteropathogenic Escherichia coli.
द्वारा: Blanca Fernandez-Ciruelos, और अन्य
प्रकाशित: (2023-12-01)

Testing stand of PMR analyzer for measuring viscosity and composition of multicomponent liquids by PMR relaxometry method
द्वारा: Nguyen Chi Kien, और अन्य
प्रकाशित: (2020-05-01)

Detection and characterization of eravacycline heteroresistance in clinical bacterial isolates
द्वारा: Yingfeng Zhang, और अन्य
प्रकाशित: (2024-03-01)

Impact of heteroresistance on treatment outcomes of people with drug-resistant TB
द्वारा: R. Crowder, और अन्य
प्रकाशित: (2024-10-01)

Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression
द्वारा: Éva Gagyi, और अन्य
प्रकाशित: (2008-12-01)

Stem Cells in PMR Practices
द्वारा: Singh AK, और अन्य
प्रकाशित: (2008-04-01)

Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage
द्वारा: Green, LR, और अन्य
प्रकाशित: (2020)

The evolution of heteroresistance via small colony variants in Escherichia coli following long term exposure to bacteriostatic antibiotics
द्वारा: Teresa Gil-Gil, और अन्य
प्रकाशित: (2024-09-01)

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence
द्वारा: Jangir, PK, और अन्य
प्रकाशित: (2023)

The Effects of Shock Vancomycin Concentrations on the Formation of Heteroresistance in Staphylococcus aureus
द्वारा: V. V. Gostev, और अन्य
प्रकाशित: (2020-12-01)

Machine learning detection of heteroresistance in Escherichia coliResearch in context
द्वारा: Andrei Guliaev, और अन्य
प्रकाशित: (2025-03-01)

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates
द्वारा: Cécile Gautier, और अन्य
प्रकाशित: (2024-04-01)

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response
द्वारा: Ana J. Choi, और अन्य
प्रकाशित: (2024-12-01)

A novel small RNA PhaS contributes to polymyxin B-heteroresistance in carbapenem-resistant Klebsiella pneumoniae
द्वारा: Zhiwei Zhao, और अन्य
प्रकाशित: (2024-12-01)

B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S
द्वारा: Catherine Jacob-Dolan, और अन्य
प्रकाशित: (2024-05-01)