Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Colistin has emerged as an important last line of defence for the treatment of infections caused by antibiotic resistant Gram-negative pathogens, but colistin resistance remains poorly understood. Here we investigate the responses of |1,000 populations of an MDR strain of P. aeruginosa to a high dos...

書誌詳細
主要な著者:	Kapel, N, diaz, J, Maclean, R
フォーマット:	Journal article
言語:	English
出版事項:	Cell Press 2022

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