Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Localized pmrB hypermutation drives the evolution of colistin heteroresistance

Colistin has emerged as an important last line of defence for the treatment of infections caused by antibiotic resistant Gram-negative pathogens, but colistin resistance remains poorly understood. Here we investigate the responses of |1,000 populations of an MDR strain of P. aeruginosa to a high dos...

書目詳細資料
Main Authors:	Kapel, N, diaz, J, Maclean, R
格式:	Journal article
語言:	English
出版:	Cell Press 2022

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