Collagen-induced arthritis as a model for rheumatoid arthritis.
Collagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that is widely used to address questions of disease pathogenesis and to validate therapeutic targets. Arthritis is normally induced in mice or rats by immunization with autologous or heterologous type II collagen in adj...
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826259315922567168 |
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| author | Williams, R |
| author_facet | Williams, R |
| author_sort | Williams, R |
| collection | OXFORD |
| description | Collagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that is widely used to address questions of disease pathogenesis and to validate therapeutic targets. Arthritis is normally induced in mice or rats by immunization with autologous or heterologous type II collagen in adjuvant. Susceptibility to collagen-induced arthritis is strongly associated with major histocompatibility complex class II genes, and the development of arthritis is accompanied by a robust T- and B-cell response to type II collagen. The chief pathological features of CIA include a proliferative synovitis with infiltration of polymorphonuclear and mononuclear cells, pannus formation, cartilage degradation, erosion of bone, and fibrosis. As in RA, pro-inflammatory cytokines, such as tumor necrosis factor alpha(TNFalpha) and interleukin (IL)-1beta, are abundantly expressed in the arthritic joints of mice with CIA, and blockade of these molecules results in a reduction of disease severity. |
| first_indexed | 2024-03-06T18:47:55Z |
| format | Journal article |
| id | oxford-uuid:0f2c743a-1057-4ef4-b8d6-4ef9214e5808 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:47:55Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:0f2c743a-1057-4ef4-b8d6-4ef9214e58082022-03-26T09:49:53ZCollagen-induced arthritis as a model for rheumatoid arthritis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0f2c743a-1057-4ef4-b8d6-4ef9214e5808EnglishSymplectic Elements at Oxford2004Williams, RCollagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that is widely used to address questions of disease pathogenesis and to validate therapeutic targets. Arthritis is normally induced in mice or rats by immunization with autologous or heterologous type II collagen in adjuvant. Susceptibility to collagen-induced arthritis is strongly associated with major histocompatibility complex class II genes, and the development of arthritis is accompanied by a robust T- and B-cell response to type II collagen. The chief pathological features of CIA include a proliferative synovitis with infiltration of polymorphonuclear and mononuclear cells, pannus formation, cartilage degradation, erosion of bone, and fibrosis. As in RA, pro-inflammatory cytokines, such as tumor necrosis factor alpha(TNFalpha) and interleukin (IL)-1beta, are abundantly expressed in the arthritic joints of mice with CIA, and blockade of these molecules results in a reduction of disease severity. |
| spellingShingle | Williams, R Collagen-induced arthritis as a model for rheumatoid arthritis. |
| title | Collagen-induced arthritis as a model for rheumatoid arthritis. |
| title_full | Collagen-induced arthritis as a model for rheumatoid arthritis. |
| title_fullStr | Collagen-induced arthritis as a model for rheumatoid arthritis. |
| title_full_unstemmed | Collagen-induced arthritis as a model for rheumatoid arthritis. |
| title_short | Collagen-induced arthritis as a model for rheumatoid arthritis. |
| title_sort | collagen induced arthritis as a model for rheumatoid arthritis |
| work_keys_str_mv | AT williamsr collageninducedarthritisasamodelforrheumatoidarthritis |