Critical role for a single leucine residue in leukemia induction by E2A-PBX1
In roughly 5% of cases of acute lymphoblastic leukemia, a chromosomal translocation leads to expression of the oncogenic protein E2A-PBX1. The N-terminal portion of E2A-PBX1, encoded by the E2A gene, is identical in sequence to the corresponding portion of the E proteins E12/E47 and includes transcr...
Main Authors: | Bayly, R, Murase, T, Hyndman, B, Savage, R, Nurmohamed, S, Munro, K, Casselman, R, Smith, S, LeBrun, D |
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Format: | Journal article |
Language: | English |
Published: |
American Society for Microbiology
2006
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