Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

BACKGROUND: The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are important goals that are central to the design of an effective antibody-based...

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Main Authors: Corti, D, Langedijk, J, Hinz, A, Seaman, MS, Vanzetta, F, Fernandez-Rodriguez, B, Silacci, C, Pinna, D, Jarrossay, D, Balla-Jhagjhoorsingh, S, Willems, B, Zekveld, M, Dreja, H, O'Sullivan, E, Pade, C, Orkin, C, Jeffs, SA, Montefiori, D, Davis, D, Weissenhorn, W, McKnight, A, Heeney, J, Sallusto, F, Sattentau, Q, Weiss, R, Lanzavecchia, A
Format: Journal article
Language:English
Published: 2010

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