Ultrasensitive amplicon barcoding for next-generation sequencing facilitating sequence error and amplification-bias correction
The ability to accurately characterize DNA variant proportions using PCR amplification is key to many genetic studies, including studying tumor heterogeneity, 16S microbiome, viral and immune receptor sequencing. We develop a novel generalizable ultrasensitive amplicon barcoding approach that signif...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Published: |
Nature Research
2020
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