Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.
We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 a...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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| _version_ | 1797053959317225472 |
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| author | Jongeneel, C Briant, L Udalova, I Sevin, A Nedospasov, SA Cambon-Thomsen, A |
| author_facet | Jongeneel, C Briant, L Udalova, I Sevin, A Nedospasov, SA Cambon-Thomsen, A |
| author_sort | Jongeneel, C |
| collection | OXFORD |
| description | We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies. |
| first_indexed | 2024-03-06T18:50:53Z |
| format | Journal article |
| id | oxford-uuid:102afab9-56ca-4d14-89a6-5258e008acb8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:50:53Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:102afab9-56ca-4d14-89a6-5258e008acb82022-03-26T09:55:05ZExtensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:102afab9-56ca-4d14-89a6-5258e008acb8EnglishSymplectic Elements at Oxford1991Jongeneel, CBriant, LUdalova, ISevin, ANedospasov, SACambon-Thomsen, AWe have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies. |
| spellingShingle | Jongeneel, C Briant, L Udalova, I Sevin, A Nedospasov, SA Cambon-Thomsen, A Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. |
| title | Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. |
| title_full | Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. |
| title_fullStr | Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. |
| title_full_unstemmed | Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. |
| title_short | Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. |
| title_sort | extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended hla haplotypes |
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