Decreased cyclin B1 expression contributes to G2 delay in human brain tumor cells after treatment with camptothecin.

Decreased cyclin B1 expression contributes to G2 delay in human brain tumor cells after treatment with camptothecin.

DNA damage produces delayed mitosis (G2/M delay) in proliferating cells, and shortening the delay sensitizes human malignant glioma and medulloblastoma cells to cytotoxic chemotherapy. Although activation of the cyclin-dependent kinase CDC2 mediates G2/M transition in all tumor cells studied to date...

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Bibliographic Details
Main Authors:	Janss, A, Maity, A, Tang, C, Muschel, R, Mckenna, W, Sutton, L, Phillips, P
Format:	Journal article
Language:	English
Published:	2001

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