Humoral immune responses to adenovirus vectors in the brain.
We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibod...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1826259553908424704 |
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| author | Kajiwara, K Byrnes, A Ohmoto, Y Charlton, H Wood, M Wood, K |
| author_facet | Kajiwara, K Byrnes, A Ohmoto, Y Charlton, H Wood, M Wood, K |
| author_sort | Kajiwara, K |
| collection | OXFORD |
| description | We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibody production to beta-galactosidase, the product of the lacZ gene, was detected later than anti-adenovirus antibody. Neutralizing antibody was not detected. This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection. |
| first_indexed | 2024-03-06T18:51:43Z |
| format | Journal article |
| id | oxford-uuid:107633e1-4199-41cb-9fd8-5bff67441c65 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:51:43Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:107633e1-4199-41cb-9fd8-5bff67441c652022-03-26T09:56:37ZHumoral immune responses to adenovirus vectors in the brain.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:107633e1-4199-41cb-9fd8-5bff67441c65EnglishSymplectic Elements at Oxford2000Kajiwara, KByrnes, AOhmoto, YCharlton, HWood, MWood, KWe have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. Apparent antibody production to beta-galactosidase, the product of the lacZ gene, was detected later than anti-adenovirus antibody. Neutralizing antibody was not detected. This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection. |
| spellingShingle | Kajiwara, K Byrnes, A Ohmoto, Y Charlton, H Wood, M Wood, K Humoral immune responses to adenovirus vectors in the brain. |
| title | Humoral immune responses to adenovirus vectors in the brain. |
| title_full | Humoral immune responses to adenovirus vectors in the brain. |
| title_fullStr | Humoral immune responses to adenovirus vectors in the brain. |
| title_full_unstemmed | Humoral immune responses to adenovirus vectors in the brain. |
| title_short | Humoral immune responses to adenovirus vectors in the brain. |
| title_sort | humoral immune responses to adenovirus vectors in the brain |
| work_keys_str_mv | AT kajiwarak humoralimmuneresponsestoadenovirusvectorsinthebrain AT byrnesa humoralimmuneresponsestoadenovirusvectorsinthebrain AT ohmotoy humoralimmuneresponsestoadenovirusvectorsinthebrain AT charltonh humoralimmuneresponsestoadenovirusvectorsinthebrain AT woodm humoralimmuneresponsestoadenovirusvectorsinthebrain AT woodk humoralimmuneresponsestoadenovirusvectorsinthebrain |