Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus.
OBJECTIVE: The aim of the study was to evaluate left ventricular diastolic function and its relation to aortic wall stiffness in patients with type 1 diabetes mellitus without coronary artery disease or hypertension. PATIENTS: Sixty-six patients with type 1 diabetes mellitus were examined by echoca...
| Главные авторы: | , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
2008
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| _version_ | 1826259554293252096 |
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| author | Karamitsos, T Karvounis, H Didangelos, T Papadopoulos, C Kachrimanidou, M Selvanayagam, J Parharidis, G |
| author_facet | Karamitsos, T Karvounis, H Didangelos, T Papadopoulos, C Kachrimanidou, M Selvanayagam, J Parharidis, G |
| author_sort | Karamitsos, T |
| collection | OXFORD |
| description | OBJECTIVE: The aim of the study was to evaluate left ventricular diastolic function and its relation to aortic wall stiffness in patients with type 1 diabetes mellitus without coronary artery disease or hypertension. PATIENTS: Sixty-six patients with type 1 diabetes mellitus were examined by echocardiography and divided into two groups according to the diastolic filling pattern determined by mitral annulus tissue Doppler velocities. Group A patients (n = 21) presented diastolic dysfunction with a peak early diastolic mitral annular velocity (Em)/peak late diastolic mitral annular velocity (Am) ratio <1 whereas in group B patients (n = 45) the Em/Am ratio was >1. Coronary artery disease was excluded based on normal thallium scintigraphy. Aortic stiffness index was calculated from aortic diameters measured by echocardiography, using accepted criteria. RESULTS: Aortic stiffness index differed significantly among the two groups. Significant correlations were found between parameters of left ventricular diastolic function (Em/Am, isovolumic relaxation time, deceleration time) and aortic stiffness index. Multiple stepwise linear regression analysis revealed aortic stiffness index (beta = -0.39, p = 0.001) and isovolumic relaxation time (beta = -0.46, p < 0.001) as the main predictors of Em/Am ratio. CONCLUSIONS: Aortic stiffness is increased in type 1 diabetic patients with left ventricular diastolic dysfunction. This impairment in aortic elastic properties seems to be related to parameters of diastolic function. |
| first_indexed | 2024-03-06T18:51:44Z |
| format | Journal article |
| id | oxford-uuid:10767bae-8437-4641-88c5-55646f4f5ac7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:51:44Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:10767bae-8437-4641-88c5-55646f4f5ac72022-03-26T09:56:37ZAortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:10767bae-8437-4641-88c5-55646f4f5ac7EnglishSymplectic Elements at Oxford2008Karamitsos, TKarvounis, HDidangelos, TPapadopoulos, CKachrimanidou, MSelvanayagam, JParharidis, G OBJECTIVE: The aim of the study was to evaluate left ventricular diastolic function and its relation to aortic wall stiffness in patients with type 1 diabetes mellitus without coronary artery disease or hypertension. PATIENTS: Sixty-six patients with type 1 diabetes mellitus were examined by echocardiography and divided into two groups according to the diastolic filling pattern determined by mitral annulus tissue Doppler velocities. Group A patients (n = 21) presented diastolic dysfunction with a peak early diastolic mitral annular velocity (Em)/peak late diastolic mitral annular velocity (Am) ratio <1 whereas in group B patients (n = 45) the Em/Am ratio was >1. Coronary artery disease was excluded based on normal thallium scintigraphy. Aortic stiffness index was calculated from aortic diameters measured by echocardiography, using accepted criteria. RESULTS: Aortic stiffness index differed significantly among the two groups. Significant correlations were found between parameters of left ventricular diastolic function (Em/Am, isovolumic relaxation time, deceleration time) and aortic stiffness index. Multiple stepwise linear regression analysis revealed aortic stiffness index (beta = -0.39, p = 0.001) and isovolumic relaxation time (beta = -0.46, p < 0.001) as the main predictors of Em/Am ratio. CONCLUSIONS: Aortic stiffness is increased in type 1 diabetic patients with left ventricular diastolic dysfunction. This impairment in aortic elastic properties seems to be related to parameters of diastolic function. |
| spellingShingle | Karamitsos, T Karvounis, H Didangelos, T Papadopoulos, C Kachrimanidou, M Selvanayagam, J Parharidis, G Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus. |
| title | Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus. |
| title_full | Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus. |
| title_fullStr | Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus. |
| title_full_unstemmed | Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus. |
| title_short | Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus. |
| title_sort | aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus |
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