La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordinates the synchronous and stoichiometric expression of...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Lahr, RM, Fonseca, BD, Ciotti, GE, Al-Ashtal, HA, Jia, J-J, Niklaus, MR, Blagden, SP, Alain, T, Berman, AJ
Formatua:	Journal article
Argitaratua:	eLife Sciences Publications 2017

Antzeko izenburuak

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs
nork: Roni M Lahr, et al.
Argitaratua: (2017-04-01)

Controversies around the function of LARP1
nork: Berman, AJ, et al.
Argitaratua: (2020)

The LARP1 homolog Slr1p controls the stability and expression of proto-5′TOP mRNAs in fission yeast
nork: Farnaz Mansouri-Noori, et al.
Argitaratua: (2023-10-01)

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
nork: Sungki Hong, et al.
Argitaratua: (2017-06-01)

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer
nork: Hopkins, T, et al.
Argitaratua: (2015)

Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane.
nork: Hao Wang, et al.
Argitaratua: (2014-01-01)

eIF3 Interacts with Selenoprotein mRNAs
nork: Hassan Hayek, et al.
Argitaratua: (2022-09-01)

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
nork: Blagden, S, et al.
Argitaratua: (2015)

eIF3 engages with 3’-UTR termini of highly translated mRNAs
nork: Santi Mestre-Fos, et al.
Argitaratua: (2025-01-01)

LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection
nork: Sandy Mattijssen, et al.
Argitaratua: (2017-09-01)

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease
nork: Anthony M. Kyriakopoulos, et al.
Argitaratua: (2021-08-01)

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
nork: Lama, Dilraj, et al.
Argitaratua: (2017)

eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions
nork: Andrei Stanciu, et al.
Argitaratua: (2022-01-01)

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity
nork: Paul Yourik, et al.
Argitaratua: (2017-11-01)

Loss of LARP4B, an early event in the tumorigenesis of brain cancer?
nork: Blagden, S, et al.
Argitaratua: (2016)

Arabidopsis thaliana eIF4E1 and eIF(iso)4E Participate in Cold Response and Promote Translation of Some Stress-Related mRNAs
nork: Kenia Salazar-Díaz, et al.
Argitaratua: (2021-09-01)

Corrigendum: eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions
nork: Andrei Stanciu, et al.
Argitaratua: (2022-04-01)

Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1
nork: Guennadi Kozlov, et al.
Argitaratua: (2024-12-01)

mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency
nork: Michael J. Holmes, et al.
Argitaratua: (2024-06-01)

The RNA-binding protein LARP1 is a cancer therapeutic target
nork: Ghazaly, E, et al.
Argitaratua: (2017)

MicroRNAs recruit eIF4E2 to repress translation of target mRNAs
nork: Shaohong Chen, et al.
Argitaratua: (2017-07-01)

Cellular cap-binding proteins associate with influenza virus mRNAs.
nork: Bier, K, et al.
Argitaratua: (2011)

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs
nork: Tamiko Nishimura, et al.
Argitaratua: (2015-06-01)

LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder
nork: James Chettle, et al.
Argitaratua: (2024-10-01)

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
nork: Marina P Volegova, et al.
Argitaratua: (2023-01-01)

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs
nork: Marina P. Volegova, et al.
Argitaratua: (2023-01-01)

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.
nork: Arti N Santhanam, et al.
Argitaratua: (2009-01-01)

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation.
nork: Yaël Mamane, et al.
Argitaratua: (2007-01-01)

eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.
nork: Andrew Bottley, et al.
Argitaratua: (2010-09-01)

Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells
nork: Manuel Bulfoni, et al.
Argitaratua: (2022-08-01)

Telocinobufagin suppresses malignant metastasis of undifferentiated thyroid carcinoma via modulation of the LARP1‐mTOR pathway
nork: Li‐Zhi Qiang, et al.
Argitaratua: (2025-03-01)

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence
nork: Lahr, R, et al.
Argitaratua: (2015)

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
Argitaratua: (2009-01-01)

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference.
nork: Arti N. Santhanam, et al.
Argitaratua: (2009-01-01)

The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci
nork: Anand K Singh, et al.
Argitaratua: (2019-03-01)

Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution
nork: Elaine Nguyen, et al.
Argitaratua: (2024-01-01)

A Novel Strategy for Regulating mRNA’s Degradation via Interfering the AUF1’s Binding to mRNA
nork: Kun-Tao Li, et al.
Argitaratua: (2022-05-01)

XRN4 and LARP1 Are Required for a Heat-Triggered mRNA Decay Pathway Involved in Plant Acclimation and Survival during Thermal Stress
nork: Rémy Merret, et al.
Argitaratua: (2013-12-01)

The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif
nork: Grishin Nick V, et al.
Argitaratua: (2009-01-01)

Elucidating the functional role and therapeutic potential of La-related protein 1B (LARP1B) in cancer and its interplay with other LARP family members
nork: Nawaz, A
Argitaratua: (2023)