La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordinates the synchronous and stoichiometric expression of...

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Detalhes bibliográficos
Principais autores:	Lahr, RM, Fonseca, BD, Ciotti, GE, Al-Ashtal, HA, Jia, J-J, Niklaus, MR, Blagden, SP, Alain, T, Berman, AJ
Formato:	Journal article
Publicado em:	eLife Sciences Publications 2017

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