Antibodies to neuronal targets in neurological and psychiatric diseases.
The role of antibodies to specific neuronal and muscle ion channels in the etiology of neuromuscular transmission disorders is now well accepted. In addition, maternal antibodies can cross the placenta and cause neonatal disease or even alter the development of the infant, raising the possibility th...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1826259650451865600 |
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| author | Vincent, A Dalton, P Clover, L Palace, J Lang, B |
| author_facet | Vincent, A Dalton, P Clover, L Palace, J Lang, B |
| author_sort | Vincent, A |
| collection | OXFORD |
| description | The role of antibodies to specific neuronal and muscle ion channels in the etiology of neuromuscular transmission disorders is now well accepted. In addition, maternal antibodies can cross the placenta and cause neonatal disease or even alter the development of the infant, raising the possibility that some neurodevelopmental conditions could be caused by maternal antibodies. Voltage-gated ion channels are expressed in the brain as well as at the neuromuscular junction, and in recent years it has become clear that antibodies to some central nervous system (CNS) channels can be associated with CNS disease. This review highlights features of these conditions, preliminary investigations into neurodevelopmental disorders, and areas for further study. |
| first_indexed | 2024-03-06T18:53:12Z |
| format | Journal article |
| id | oxford-uuid:10f30bad-ed2e-455b-b420-3a4aa76b10e3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:53:12Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:10f30bad-ed2e-455b-b420-3a4aa76b10e32022-03-26T09:59:20ZAntibodies to neuronal targets in neurological and psychiatric diseases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:10f30bad-ed2e-455b-b420-3a4aa76b10e3EnglishSymplectic Elements at Oxford2003Vincent, ADalton, PClover, LPalace, JLang, BThe role of antibodies to specific neuronal and muscle ion channels in the etiology of neuromuscular transmission disorders is now well accepted. In addition, maternal antibodies can cross the placenta and cause neonatal disease or even alter the development of the infant, raising the possibility that some neurodevelopmental conditions could be caused by maternal antibodies. Voltage-gated ion channels are expressed in the brain as well as at the neuromuscular junction, and in recent years it has become clear that antibodies to some central nervous system (CNS) channels can be associated with CNS disease. This review highlights features of these conditions, preliminary investigations into neurodevelopmental disorders, and areas for further study. |
| spellingShingle | Vincent, A Dalton, P Clover, L Palace, J Lang, B Antibodies to neuronal targets in neurological and psychiatric diseases. |
| title | Antibodies to neuronal targets in neurological and psychiatric diseases. |
| title_full | Antibodies to neuronal targets in neurological and psychiatric diseases. |
| title_fullStr | Antibodies to neuronal targets in neurological and psychiatric diseases. |
| title_full_unstemmed | Antibodies to neuronal targets in neurological and psychiatric diseases. |
| title_short | Antibodies to neuronal targets in neurological and psychiatric diseases. |
| title_sort | antibodies to neuronal targets in neurological and psychiatric diseases |
| work_keys_str_mv | AT vincenta antibodiestoneuronaltargetsinneurologicalandpsychiatricdiseases AT daltonp antibodiestoneuronaltargetsinneurologicalandpsychiatricdiseases AT cloverl antibodiestoneuronaltargetsinneurologicalandpsychiatricdiseases AT palacej antibodiestoneuronaltargetsinneurologicalandpsychiatricdiseases AT langb antibodiestoneuronaltargetsinneurologicalandpsychiatricdiseases |