Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis.
Carboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA.
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2005
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| _version_ | 1826259682490056704 |
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| author | Sorensen, J Sleeman, M Schofield, C |
| author_facet | Sorensen, J Sleeman, M Schofield, C |
| author_sort | Sorensen, J |
| collection | OXFORD |
| description | Carboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA. |
| first_indexed | 2024-03-06T18:53:40Z |
| format | Journal article |
| id | oxford-uuid:1119e63e-35b7-493f-b9b9-e4e4a84f89f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:53:40Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:1119e63e-35b7-493f-b9b9-e4e4a84f89f12022-03-26T10:00:18ZSynthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1119e63e-35b7-493f-b9b9-e4e4a84f89f1EnglishSymplectic Elements at Oxford2005Sorensen, JSleeman, MSchofield, CCarboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA. |
| spellingShingle | Sorensen, J Sleeman, M Schofield, C Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. |
| title | Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. |
| title_full | Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. |
| title_fullStr | Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. |
| title_full_unstemmed | Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. |
| title_short | Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. |
| title_sort | synthesis of deuterium labelled l and d glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase carb implications for carbapenem biosynthesis |
| work_keys_str_mv | AT sorensenj synthesisofdeuteriumlabelledlanddglutamatesemialdehydesandtheirevaluationassubstratesforcarboxymethylprolinesynthasecarbimplicationsforcarbapenembiosynthesis AT sleemanm synthesisofdeuteriumlabelledlanddglutamatesemialdehydesandtheirevaluationassubstratesforcarboxymethylprolinesynthasecarbimplicationsforcarbapenembiosynthesis AT schofieldc synthesisofdeuteriumlabelledlanddglutamatesemialdehydesandtheirevaluationassubstratesforcarboxymethylprolinesynthasecarbimplicationsforcarbapenembiosynthesis |