Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis.
Carboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA.
Príomhchruthaitheoirí: | Sorensen, J, Sleeman, M, Schofield, C |
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Formáid: | Journal article |
Teanga: | English |
Foilsithe / Cruthaithe: |
2005
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Míreanna comhchosúla
Míreanna comhchosúla
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Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.
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