Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide
Two drug-inorganic composites involving vitamin C (VC) intercalated in Mg-Al and Mg-Fe layered double hydroxides (LDHs) have been synthesized by the calcination-rehydration (reconstruction) method. Powder X-ray diffraction (XRD), Fourier transform infrared (FTIR), and UV-vis absorption spectroscopy...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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2013
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| _version_ | 1797054208392822784 |
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| author | Gao, X Xie, J Chang, T Lei, L Gao, P O'Hare, D |
| author_facet | Gao, X Xie, J Chang, T Lei, L Gao, P O'Hare, D |
| author_sort | Gao, X |
| collection | OXFORD |
| description | Two drug-inorganic composites involving vitamin C (VC) intercalated in Mg-Al and Mg-Fe layered double hydroxides (LDHs) have been synthesized by the calcination-rehydration (reconstruction) method. Powder X-ray diffraction (XRD), Fourier transform infrared (FTIR), and UV-vis absorption spectroscopy indicate a successful intercalation of VC into the interlayer galleries of the LDH host. Studies of VC release from the LDHs in deionised water and in aqueous CO solutions imply that MgAl-VC LDH is a better controlled release system than MgFe-VC LDH. Analysis of the release profiles using a number of kinetic models suggests a solution-dependent release mechanism, and a diffusion-controlled deintercalation mechanism in deionised water, but an ion exchange process in CO solution. © 2013 Elsevier Inc. |
| first_indexed | 2024-03-06T18:53:57Z |
| format | Journal article |
| id | oxford-uuid:112f5e7a-8595-4ef3-a0bc-e4e0005313e6 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:53:57Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:112f5e7a-8595-4ef3-a0bc-e4e0005313e62022-03-26T10:00:51ZIntercalation and controlled release properties of vitamin C intercalated layered double hydroxideJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:112f5e7a-8595-4ef3-a0bc-e4e0005313e6Symplectic Elements at Oxford2013Gao, XXie, JChang, TLei, LGao, PO'Hare, DTwo drug-inorganic composites involving vitamin C (VC) intercalated in Mg-Al and Mg-Fe layered double hydroxides (LDHs) have been synthesized by the calcination-rehydration (reconstruction) method. Powder X-ray diffraction (XRD), Fourier transform infrared (FTIR), and UV-vis absorption spectroscopy indicate a successful intercalation of VC into the interlayer galleries of the LDH host. Studies of VC release from the LDHs in deionised water and in aqueous CO solutions imply that MgAl-VC LDH is a better controlled release system than MgFe-VC LDH. Analysis of the release profiles using a number of kinetic models suggests a solution-dependent release mechanism, and a diffusion-controlled deintercalation mechanism in deionised water, but an ion exchange process in CO solution. © 2013 Elsevier Inc. |
| spellingShingle | Gao, X Xie, J Chang, T Lei, L Gao, P O'Hare, D Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide |
| title | Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide |
| title_full | Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide |
| title_fullStr | Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide |
| title_full_unstemmed | Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide |
| title_short | Intercalation and controlled release properties of vitamin C intercalated layered double hydroxide |
| title_sort | intercalation and controlled release properties of vitamin c intercalated layered double hydroxide |
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